Welcome to the Lindenbach lab! We are a biomedical research group led by Dr. Brett Lindenbach, Associate Professor in the Department of Microbial Pathogenesis at Yale School of Medicine.
The focus of our research is on the replication of hepatitis C virus (HCV) and related positive-strand RNA viruses. HCV infects more than 120 million people world-wide, causing acute and chronic liver disease that can develop into liver cancer and the leading indication for liver transplantation in the United States. Another viral pathogen that we study is dengue virus, which infects 50-100 million people annually and causes 25,000 deaths.
We utilize a combination of viral genetics, biochemistry, and cell biological approaches to ask fundamental questions about how positive-strand RNA viruses replicate. By answering these questions, we are contributing to the development of improved strategies to prevent and treat viral infections.
We place a high priority on training and mentorship, providing a strong environment for trainees to develop innovative approaches and progress as scientists. Have a look and feel free to contact us with any questions.
[Lifecycle of the Flaviviridae]
Our trans-complementation paper was published in PLoS Pathogens. Also, our NIAID R21 application, "Bacterial effectors as probes to study (+) RNA virus-host cell biology" received a priority score of 21.
Laura Claessens, a master's student from Leiden University in the Netherlands will be visiting our lab. Welcome Laura!
Michael Parker, graduate student in the Yale Immunology Program, has joined the the lab for his thesis work. Welcome Michael! Also, Andrew Kohlway, a student who worked in our lab and Anna Pyle's lab, defended his thesis. Congratulations Andrew!